Package: phase1RMD 1.0.9

phase1RMD: Repeated Measurement Design for Phase I Clinical Trial

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Authors:Jun Yin, Yu Du, Sumithra Mandrekar

phase1RMD_1.0.9.tar.gz
phase1RMD_1.0.9.zip(r-4.7-any)phase1RMD_1.0.9.zip(r-4.6-any)phase1RMD_1.0.9.zip(r-4.5-any)
phase1RMD_1.0.9.tgz(r-4.6-any)phase1RMD_1.0.9.tgz(r-4.5-any)
phase1RMD_1.0.9.tar.gz(r-4.7-any)phase1RMD_1.0.9.tar.gz(r-4.6-any)
phase1RMD_1.0.9.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
phase1RMD/json (API)

# Install 'phase1RMD' in R:
install.packages('phase1RMD', repos = c('https://vivienjyin.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/vivienjyin/phase1rmd/issues

Uses libs:
  • jags– Just Another Gibbs Sampler for Bayesian MCMC
  • c++– GNU Standard C++ Library v3
Datasets:

On CRAN:

Conda:

jagscpp

2.70 score 8 scripts 275 downloads 1 mentions 8 exports 24 dependencies

Last updated from:af32af2e32. Checks:9 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-develOK180
source / vignettesOK184
linux-releaseOK153
macos-releaseOK162
macos-oldrelOK156
windows-develOK102
windows-releaseOK101
windows-oldrelOK102
wasm-releaseOK129

Exports:GenToxProbparmplot.RunRMDValRunRMDRunRMDEFFSimRMDSimRMDEFFTox2nTTP

Dependencies:arrayhelpersbootclicodacpp11farverggplot2gluegtableisobandlabelinglatticelifecyclemvtnormR6RColorBrewerrjagsrlangS7scalessvUnitvctrsviridisLitewithr