Package: phase1RMD 1.0.9

phase1RMD: Repeated Measurement Design for Phase I Clinical Trial

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Authors:Jun Yin, Yu Du, Sumithra Mandrekar

phase1RMD_1.0.9.tar.gz
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phase1RMD_1.0.9.tgz(r-4.4-any)phase1RMD_1.0.9.tgz(r-4.3-any)
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phase1RMD.pdf |phase1RMD.html
phase1RMD/json (API)

# Install 'phase1RMD' in R:
install.packages('phase1RMD', repos = c('https://vivienjyin.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/vivienjyin/phase1rmd/issues

Uses libs:
  • jags– Just Another Gibbs Sampler for Bayesian MCMC
  • c++– GNU Standard C++ Library v3
Datasets:

On CRAN:

2.70 score 8 scripts 171 downloads 8 exports 34 dependencies

Last updated 3 years agofrom:af32af2e32. Checks:OK: 7. Indexed: yes.

TargetResultDate
Doc / VignettesOKOct 29 2024
R-4.5-winOKOct 29 2024
R-4.5-linuxOKOct 29 2024
R-4.4-winOKOct 29 2024
R-4.4-macOKOct 29 2024
R-4.3-winOKOct 29 2024
R-4.3-macOKOct 29 2024

Exports:GenToxProbparmplot.RunRMDValRunRMDRunRMDEFFSimRMDSimRMDEFFTox2nTTP

Dependencies:arrayhelpersbootclicodacolorspacefansifarverggplot2gluegtableisobandlabelinglatticelifecyclemagrittrMASSMatrixmgcvmunsellmvtnormnlmepillarpkgconfigR6RColorBrewerrjagsrlangscalessvUnittibbleutf8vctrsviridisLitewithr